Re: Brandi R: I think it would be helpful to list why the space doesn't make you feel comfortable. Are those feelings attached to objects? Then discard of the objects. Replace them with things things that interest you. Alternatively, give a space a breath of fresh air by rearranging things.
Re: Sarah A: Beautiful poet, Sylvia Plath, always claimed that "Your room is not a prison, you are." Try going out of your comfort zone, and this can manifest itself in how you rearrange your room. Stick to a color scheme or theme. Usually the way you feel about your life can resemble the status of your room, so making your room look and feel good makes you feel organized in the end.